The African killifish: A short-lived vertebrate model to study the biology of sarcopenia and longevity.

ABSTRACT: Sarcopenia, the age-related decline in muscle function, places a considerable burden on health-care systems. While the stereotypic hallmarks of sarcopenia are well characterized, their contribution to muscle wasting remains elusive, which is partly due to the limited availability of animal models. Here, we have performed cellular and molecular characterization of skeletal muscle from the African killifish-an extremely short-lived vertebrate-revealing that while many characteristics deteriorate with increasing age, supporting the use of killifish as a model for sarcopenia research, some features surprisingly reverse to an "early-life" state in the extremely old stages. This suggests that in extremely old animals, there may be mechanisms that prevent further deterioration of skeletal muscle,

SUBMITTER: Ruparelia AA 

PROVIDER: S-EPMC10776123 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature