Medication and bone health in multiple sclerosis: A systematic review and meta-analysis.

ABSTRACT:

Background

People with multiple sclerosis (MS) are often prescribed medications associated with adverse effects on bone health. However, it is unclear whether these medications incur decreases in areal bone mineral density (aBMD) and higher fracture risk in this population.

Objective

To investigate the effects of commonly used medications on aBMD and fracture risk among people with MS.

Methods

MEDLINE, Embase, Scopus, CINAHL, and Web of Science were searched from their inception until February 5, 2023. We included randomized controlled trials as well as cross-sectional, retrospective, and prospective studies investigating whether glucocorticoids, immunomodulators, antidepressants, anticonvulsants, anxiolytics, opioids, or antipsychotics influenced aBMD or fracture ris

SUBMITTER: Cahyadi M 

PROVIDER: S-EPMC10776270 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature