Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets.

ABSTRACT:

Background/aims

To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets.

Methods

We conducted Mendelian randomization (MR) to assess the causal role of circulating complements in the risk of non-viral liver diseases. A complement-centric protein interaction network was constructed to explore biological functions and identify potential therapeutic options.

Results

In the MR analysis, genetically predicted levels of complement C1q C chain (C1QC) were positively associated with the risk of autoimmune hepatitis (odds ratio 1.125, 95% confidence interval 1.018-1.244), while complement factor H-related protein 5 (CFHR5) was positively associated with the risk of primary sclerosing cholangitis

SUBMITTER: Shi Y 

PROVIDER: S-EPMC10776287 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature