Erectile function and androgen and estrogen beta receptor gene polymorphisms in acromegalic men.

ABSTRACT:

Purpose

Sexual dysfunctions are often experienced by male patients with acromegaly, due to a combination of hypogonadism and other comorbidities, but are a scarcely investigated complication. Erectile dysfunction is also closely related to cardiovascular diseases through endothelial dysfunction. Therefore, this project aimed to assess the prevalence of erectile dysfunction in a population of acromegalic men and evaluate its association with cardio-metabolic disorders, also exploring associations with androgen and estrogen receptor gene polymorphisms.

Methods

Sexually active men aged 18-65 with previous diagnosis of acromegaly were recruited. Clinical and laboratory data were retrospectively collected. Each patient also provided a blood sample for AR and ERβ gene polymorphism

SUBMITTER: Pallotti F 

PROVIDER: S-EPMC10776471 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature