Computational fluid dynamics simulation of a jet crystallizer for continuous crystallization of lovastatin.

ABSTRACT: Continuous crystallization of lovastatin from a lovastatin-methanol solution and water as the anti-solvent in an impinging jet crystallizer is investigated using a computational fluid dynamics model. To capture the important phenomena, the model is coupled with micro-mixing, population balance, and related energy balance equations. It is implemented in OpenFOAM and validated against experimental data, where a fairly good agreement is found. The effects of key process parameters on the crystallization performance are also studied using the validated model. The results show that increasing the inlet jet velocity from 1 to 4 m/s yields a much narrower size distribution and 70% reduction in the mean crystal size. The four-fold increase in the inlet jet velocity also reduces the crystal product

SUBMITTER: Zarei M 

PROVIDER: S-EPMC10776609 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature