Neurocognitive correlates of semantic memory navigation in Parkinson's disease.

ABSTRACT: Cognitive studies on Parkinson's disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients' neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., 'sun') and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive statu

SUBMITTER: Toro-Hernandez FD 

PROVIDER: S-EPMC10776628 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature