Erythropoiesis in Cushing syndrome: sex-related and subtype-specific differences. Results from a monocentric study.

ABSTRACT:

Context

Cushing syndrome (CS) is associated with different hematological abnormalities. Nevertheless, conflicting data about erythropoiesis in CS have been reported. Furthermore, it is unclear whether CS sex and subtype-specific alterations in red blood cells (RBC) parameters are present.

Objective

To investigate sex and subtype-specific changes in RBC in patients with CS at initial diagnosis and after remission.

Design

Retrospective, monocentric study including 210 patients with CS (women, n = 162) matched 1:1 for sex and age to patients with pituitary microadenomas or adrenal incidentalomas (both hormonally inactive). RBC parameters were evaluated at initial diagnosis and after remission.

Results

Women with CS had higher hematocrit (median 42.2 vs 39.7%), hem

SUBMITTER: Detomas M 

PROVIDER: S-EPMC10776705 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature