Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice.

ABSTRACT: The vagus nerve crucially affects emotions and psychiatric disorders. However, the detailed neurophysiological dynamics of the vagus nerve in response to emotions and its associated pathological changes remain unclear. In this study, we demonstrated that the spike rates of the cervical vagus nerve change depending on anxiety behavior in an elevated plus maze test, and these changes were eradicated in stress-susceptible male mice. Furthermore, instantaneous spike rates of the vagus nerve were negatively and positively correlated with the power of 2-4 Hz and 20-30 Hz oscillations, respectively, in the prefrontal cortex and amygdala. The oscillations also underwent dynamic changes depending on the behavioral state in the elevated plus maze, and these changes were no longer observed in stress-

SUBMITTER: Okonogi T 

PROVIDER: S-EPMC10776769 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature