Non-Faradaic optoelectrodes for safe electrical neuromodulation.

ABSTRACT: Nanoscale optoelectrodes hold the potential to stimulate optically individual neurons and intracellular organelles, a challenge that demands both a high-density of photoelectron storage and significant charge injection. Here, we report that zinc porphyrin, commonly used in dye-sensitized solar cells, can be self-assembled into nanorods and then coated by TiO₂. The J-aggregated zinc porphyrin array enables long-range exciton diffusion and allows for fast electron transfer into TiO₂. The formation of TiO₂(e^-) attracts positive charges around the neuron membrane, contributing to the induction of action potentials. Far-field cranial irradiation of the motor cortex using a 670 nm laser or an 850 nm femtosecond laser can modulate local neuronal firing

SUBMITTER: Chen J 

PROVIDER: S-EPMC10776784 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature