Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability.

ABSTRACT: In recent years, primary familial brain calcification (PFBC), a rare neurological disease characterized by a wide spectrum of cognitive disorders, has been associated to mutations in the sodium (Na)-Phosphate (Pi) co-transporter SLC20A2. However, the functional roles of the Na-Pi co-transporters in the brain remain still largely elusive. Here we show that Slc20a1 (PiT-1) and Slc20a2 (PiT-2) are the most abundant Na-Pi co-transporters expressed in the brain and are involved in the control of hippocampal-dependent learning and memory. We reveal that Slc20a1 and Slc20a2 are differentially distributed in the hippocampus and associated with independent gene clusters, suggesting that they influence cognition by different mechanisms. Accordingly, using a combination of molecular, electrophysiolog

SUBMITTER: Ramos-Brossier M 

PROVIDER: S-EPMC10776841 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature