Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain.

ABSTRACT: The migration of neural progenitor cells (NPCs) to their final destination during development follows well-defined pathways, such as along blood vessels. Cells originating from the highly malignant tumor glioblastoma (GBM) seem to exploit similar routes for infiltrating the brain parenchyma. In this report, we have examined the migration of GBM cells using three-dimensional high-resolution confocal microscopy in brain tumors derived from eight different human GBM cell lines xenografted into immunodeficient mice. The primary invasion routes identified were long-distance migration along white matter tracts and local migration along blood vessels. We found that GBM cells in the majority of tumors (6 out of 8) did not exhibit association with blood vessels. These tumors, derived from low lamin

SUBMITTER: Gupta RK 

PROVIDER: S-EPMC10776844 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature