11-deoxycortisol positively correlates with T cell immune traits in physiological conditions.

ABSTRACT:

Background

Endogenous steroid hormones have significant effects on inflammatory and immune processes, but the immunological activities of steroidogenesis precursors remain largely unexplored.

Methods

We conducted a systematic approach to examine the association between steroid hormones profile and immune traits in a cohort of 534 healthy volunteers. Serum concentrations of steroid hormones and their precursors (cortisol, progesterone, testosterone, androstenedione, 11-deoxycortisol and 17-OH progesterone) were determined by liquid chromatography-tandem mass spectrometry. Immune traits were evaluated by quantifying cellular composition of the circulating immune system and ex vivo cytokine responses elicited by major human pathogens and microbial ligands. An independent cohort

SUBMITTER: Peng C 

PROVIDER: S-EPMC10776925 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature