Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis.

ABSTRACT:

Background

Iron overload due to the excessive use of parenteral iron in haemodialysis is now an increasingly recognised clinical issue. Before erythropoiesis-stimulating agents (ESA) were introduced, a specific feature of patients treated by dialysis and having iron overload was that iron levels in the bone marrow were paradoxically low in most of them, despite severe hepatosplenic siderosis. Whether or not this paradox persists in the actual ESA era was unknown until recently, when an autopsy study in 21 patients treated by haemodialysis revealed similarities between liver and bone marrow iron content. The aim of this study was to further explore these recent findings in a cohort of alive patients on dialysis and to analyse the determinants of iron bone marrow.

Methods

Live

SUBMITTER: Rostoker G 

PROVIDER: S-EPMC10776950 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature