Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii.

ABSTRACT: A rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba. Currently, no therapeutic agent can completely eradicate or prevent GAE. Synthetic compounds are a likely source of bioactive compounds for developing new drugs. This study synthesized seventeen 1,4-benzothiazine derivatives (I -XVII) by a base-catalyzed one-pot reaction of 2-amino thiophenol with substituted bromo acetophenones. Different spectroscopic techniques, such as EI-MS, ¹H-, and ¹³C NMR (only for the new compounds), were used for the structural characterization and conformation of compounds. These compounds were assessed for the first time against A

SUBMITTER: Alishba 

PROVIDER: S-EPMC10776951 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature