HSPB8 Facilitates the Oncogenesis and Advancement of Bladder Cancer via Activation of HSP27.

ABSTRACT: Bladder cancer (BCa) stands as a significant malignancy within the genitourinary system. Notably, heat shock proteins (HSPs) exhibit elevated expression in cells subjected to environmental stresses and have been linked to the progression of many human malignancies. Among these, the functional implications and specific mechanism of HSPB8 in BCa have yet to be fully explored. In this study, we measured HSPB8 expression in both BCa tissues and various cell lines, further delving into its influence on cellular behaviors. Our observations pinpoint an upregulation of HSPB8 in BCa, a trend strongly associated with more advanced clinical manifestations. Suppressing HSPB8 exhibited marked reductions in cell proliferation and migration capabilities, while simultaneously amplifying apoptosis and indu

SUBMITTER: Du W 

PROVIDER: S-EPMC10777032 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature