Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders.

ABSTRACT:

Introduction

Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown.

Methods

We acquired functional MRI scans during an emotional face task in participants with PTSD + CPD (n = 34), PTSD + BPD (n = 24), PTSD + BPD + CPD (n = 18) and controls (n = 30). We used ANCOVAs and Bayesian analyses on specific ROIs in a fearful vs. scrambled faces contrast. We also investigated associations with clinical measures.

Results

There were no robust differences in brain activation between the groups with ANCOVAs. Transdiagnostically, we found a negative association between severity of dissociation and right insula and right dmPFC a

SUBMITTER: Aarts I 

PROVIDER: S-EPMC10777111 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature