A systematic review of preclinical studies evaluating the association between nicotine and the initiation and progression of cancer.

ABSTRACT:

Background

The association between cigarette smoking and the increased risk of many cancers is well established. Conversely, epidemiological studies of smokeless tobacco demonstrate decreased risk, or no elevated risk, of certain cancers versus smoking. However, it is unclear what role, if any, nicotine plays in these associations. The objective of this systematic review was to synthesize the available evidence from preclinical studies that examined the potential association between nicotine and the initiation and/or progression of cancer.

Methods

MEDLINE, Embase, PsychInfo, and Cochrane Database of Systematic Reviews were searched for articles published from inception until February 13, 2022. Studies were eligible for inclusion if they evaluated animal cancer or tumor model

SUBMITTER: Kim MM 

PROVIDER: S-EPMC10777222 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature