Organ Preservation and Survival by Clinical Response Grade in Patients With Rectal Cancer Treated With Total Neoadjuvant Therapy: A Secondary Analysis of the OPRA Randomized Clinical Trial.

ABSTRACT:

Importance

Assessing clinical tumor response following completion of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer is paramount to select patients for watch-and-wait treatment.

Objective

To assess organ preservation (OP) and oncologic outcomes according to clinical tumor response grade.

Design, setting, and participants

This was secondary analysis of the Organ Preservation in Patients with Rectal Adenocarcinoma trial, a phase 2, nonblinded, multicenter, randomized clinical trial. Randomization occurred between April 2014 and March 2020. Eligible participants included patients with stage II or III rectal adenocarcinoma. Data analysis occurred from March 2022 to July 2023.

Intervention

Patients were randomized to induction chemot

SUBMITTER: Thompson HM 

PROVIDER: S-EPMC10777257 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature