Atopic and non-atopic effects of fish oil supplementation during pregnancy.

ABSTRACT:

Background

We recently conducted a double-blinded randomised controlled trial showing that fish-oil supplementation during pregnancy reduced the risk of persistent wheeze or asthma in the child by 30%. Here, we explore the mechanisms of the intervention.

Methods

736 pregnant women were given either placebo or n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in the third trimester in a randomised controlled trial. Deep clinical follow-up of the 695 children in the trial was done at 12 visits until age 6 years, including assessment of genotype at the fatty acid desaturase (FADS) locus, plasma fatty acids, airway DNA methylation, gene expression, microbiome and metabolomics.

Results

Supplementation with n-3 LCPUFA reduced the overall risk of non-atopic asthma by 73%

SUBMITTER: Bisgaard H 

PROVIDER: S-EPMC10777305 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature