A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action.

ABSTRACT: The physical and chemical properties of paddlewheel diruthenium compounds are highly dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare the ability of two diruthenium compounds, [Ru₂Cl(D-p-FPhF)(O₂CCH₃)₃]·H₂O (1) (D-p-FPhF^- = N,N'-bis(4-fluorophenyl)formamidinate) and K₃[Ru₂(O₂CO)₄]·3H₂O (2), to act as inhibitors of amyloid aggregation of the Aβ_1-42 peptide and its peculiar fragments, Aβ_1-16 and Aβ_21-40. A wide range of biophysical techniques has been used to determine the inhibition capacity against aggregation and the possible mechanism of action of these compoun

SUBMITTER: La Manna S 

PROVIDER: S-EPMC10777406 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature