Benchtop Models of Patient-Specific Intraventricular Flow During Heart Failure and LVAD Support.

ABSTRACT: The characterization of intraventricular flow is critical to evaluate the efficiency of fluid transport and potential thromboembolic risk but challenging to measure directly in advanced heart failure (HF) patients with left ventricular assist device (LVAD) support. The study aims to validate an in-house mock loop (ML) by simulating specific conditions of HF patients with normal and prosthetic mitral valves (MV) and LVAD patients with small and dilated left ventricle volumes, then comparing the flow-related indices result of vortex parameters, residence time (RT), and shear-activation potential (SAP). Patient-specific inputs for the ML studies included heart rate, end-diastolic and end-systolic volumes, ejection fraction, aortic pressure, E/A ratio, and LVAD speed. The ML effectively replic

SUBMITTER: Vu V 

PROVIDER: S-EPMC10777504 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature