Ontology highlight
ABSTRACT:
SUBMITTER: Boinpally R
PROVIDER: S-EPMC10777605 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Clinical and translational science 20240101 1
Since the discovery of calcitonin gene-related peptide (CGRP) in 1982, its integral role in migraine pathophysiology, specifically migraine pain, has been demonstrated through cumulative scientific discoveries that have led to the development and approval of migraine-specific therapeutics. Today, eight drugs, including monoclonal antibodies and small molecule CGRP receptor antagonists, known as gepants, have received approval for acute or preventive treatment of migraine. The primary mechanism o ...[more]