Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation.

ABSTRACT:

Background

Transcriptome-wide association studies have been successful in identifying candidate susceptibility genes for colorectal cancer (CRC). To strengthen susceptibility gene discovery, we conducted a large transcriptome-wide association study and an alternative splicing transcriptome-wide association study in CRC using improved genetic prediction models and performed in-depth functional investigations.

Methods

We analyzed RNA-sequencing data from normal colon tissues and genotype data from 423 European descendants to build genetic prediction models of gene expression and alternative splicing and evaluated model performance using independent RNA-sequencing data from normal colon tissues of the Genotype-Tissue Expression Project. We applied the verified models to genome-

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10777674 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature