Short-chain fatty acids and insulin sensitivity: a systematic review and meta-analysis.

ABSTRACT:

Context

There is substantial evidence that reduced short-chain fatty acids (SCFAs) in the gut are associated with obesity and type 2 diabetes, although findings from clinical interventions that can increase SCFAs are inconsistent.

Objective

This systematic review and meta-analysis aimed to assess the effect of SCFA interventions on fasting glucose, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR).

Data sources

Relevant articles published up to July 28, 2022, were extracted from PubMed and Embase using the MeSH (Medical Subject Headings) terms of the defined keywords [(short-chain fatty acids) AND (obesity OR diabetes OR insulin sensitivity)] and their synonyms. Data analyses were performed independently by two researchers who used the

SUBMITTER: Pham NHT 

PROVIDER: S-EPMC10777678 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature