T₂* Imaging Assessment of Neoadjuvant Radiation Therapy Combined With Pharmacological Ascorbate in Extremity Soft-Tissue Sarcomas: A Pilot Study.

ABSTRACT:

Background

Extremity soft-tissue sarcomas (STS) are commonly treated with neoadjuvant radiation therapy followed by surgical resection. However, the pathological near-complete response rate is low (9-25%). Noninvasive imaging assessment that predicts treatment response before and during treatment is desirable to optimize treatment regimens. This pilot study aimed to investigate the application of a quantitative MRI parameter, T₂*, in assessing neoadjuvant radiation therapy combined with pharmacological ascorbate in extremity STS.

Methods

This prospective cohort study included seven patients diagnosed with extremity STS and scheduled to receive neoadjuvant radiation therapy combined with pharmacological ascorbate. T₂* maps were obtained from each patient

SUBMITTER: Lee CY 

PROVIDER: S-EPMC10777695 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature