Molecular physiological characterization of the dynamics of persister formation in <i>Staphylococcus aureus</i>.

ABSTRACT: Bacteria possess the ability to enter a growth-arrested state known as persistence in order to survive antibiotic exposure. Clinically, persisters are regarded as the main causative agents for chronic and recurrent infectious diseases. To combat this antibiotic-tolerant population, a better understanding of the molecular physiology of persisters is required. In this study, we collected samples at different stages of the biphasic kill curve to reveal the dynamics of the cellular molecular changes that occur in the process of persister formation. After exposure to antibiotics with different modes of action, namely, vancomycin and enrofloxacin, similar persister levels were obtained. Both shared and distinct stress responses were enriched for the respective persister populations. However, the

SUBMITTER: Liu S 

PROVIDER: S-EPMC10777834 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature