Oncostatin M Reduces Pathological Neovascularization in the Retina Through Muller Cell Activation.

ABSTRACT:

Purpose

Continuous vision loss due to vasoproliferative eye disease still represents an unsolved issue despite anti-vascular endothelial growth factor (VEGF) therapy. The impact of signal transducer and activator of transcription 3 (STAT3) signaling on retinal angiogenesis and its potential use as a therapeutic target remain controversial. In vitro, oncostatin M (OSM), as a strong STAT3 activator, possesses robust proangiogenic activity. This study investigated to what extent the proangiogenic effects of OSM translate to the in vivo setting of vasoproliferative eye disease.

Methods

The in vitro effect of OSM on endothelial cells was investigated in the spheroid sprouting assay and through RNA sequencing. The mouse model for oxygen-induced retinopathy (OIR) was used to evalua

SUBMITTER: Rapp J 

PROVIDER: S-EPMC10777876 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature