Evolving CAR-T-Cell Therapy for Cancer Treatment: From Scientific Discovery to Cures.

ABSTRACT: In recent years, chimeric antigen receptor (CAR)-T-cell therapy has emerged as the most promising immunotherapy for cancer that typically uses patients' T cells and genetically engineered them to target cancer cells. Although recent improvements in CAR-T-cell therapy have shown remarkable success for treating hematological malignancies, the heterogeneity in tumor antigens and the immunosuppressive nature of the tumor microenvironment (TME) limits its efficacy in solid tumors. Despite the enormous efforts that have been made to make CAR-T-cell therapy more effective and have minimal side effects for treating hematological malignancies, more research needs to be conducted regarding its use in the clinic for treating various other types of cancer. The main concern for CAR-T-cell therapy is se

SUBMITTER: Majumder A 

PROVIDER: S-EPMC10777914 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature