Complex Spatio-Temporal Interplay of Distinct Immune and Bone Cell Subsets during Bone Fracture Healing.

ABSTRACT:

Background

The healing of a bone injury is a highly complex process involving a multitude of different tissue and cell types, including immune cells, which play a major role in the initiation and progression of bone regeneration.

Methods

We histologically analyzed the spatio-temporal occurrence of cells of the innate immune system (macrophages), the adaptive immune system (B and T lymphocytes), and bone cells (osteoblasts and osteoclasts) in the fracture area of a femoral osteotomy over the healing time. This study was performed in a bone osteotomy gap mouse model. We also investigated two key challenges of successful bone regeneration: hypoxia and revascularization.

Results

Macrophages were present in and around the fracture gap throughout the entire healing period.

SUBMITTER: Schlundt C 

PROVIDER: S-EPMC10777943 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature