Exploiting the DNA Damage Response for Prostate Cancer Therapy.
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ABSTRACT:
SUBMITTER: Stracker TH
PROVIDER: S-EPMC10777950 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
Exploiting the DNA Damage Response for Prostate Cancer Therapy.
Stracker Travis H TH Osagie Oloruntoba I OI Escorcia Freddy E FE Citrin Deborah E DE
Cancers 20231223 1
Prostate cancers that progress despite androgen deprivation develop into castration-resistant prostate cancer, a fatal disease with few treatment options. In this review, we discuss the current understanding of prostate cancer subtypes and alterations in the DNA damage response (DDR) that can predispose to the development of prostate cancer and affect its progression. We identify barriers to conventional treatments, such as radiotherapy, and discuss the development of new therapies, many of whic ...[more]
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