A Microfluidics Approach for Ovarian Cancer Immune Monitoring in an Outpatient Setting.

ABSTRACT: Among cancer diagnoses in women, ovarian cancer has the fifth-highest mortality rate. Current treatments are unsatisfactory, and new therapies are highly needed. Immunotherapies show great promise but have not reached their full potential in ovarian cancer patients. Implementation of an immune readout could offer better guidance and development of immunotherapies. However, immune profiling is often performed using a flow cytometer, which is bulky, complex, and expensive. This equipment is centralized and operated by highly trained personnel, making it cumbersome and time-consuming. We aim to develop a disposable microfluidic chip capable of performing an immune readout with the sensitivity needed to guide diagnostic decision making as close as possible to the patient. As a proof of concept

SUBMITTER: Libbrecht S 

PROVIDER: S-EPMC10778191 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature