Adenosine Receptor mRNA Expression in Frontal Cortical Neurons in Schizophrenia.

ABSTRACT: Schizophrenia is a devastating neuropsychiatric disorder associated with the dysregulation of glutamate and dopamine neurotransmitter systems. The adenosine system is an important neuroregulatory system in the brain that modulates glutamate and dopamine signaling via the ubiquitously expressed adenosine receptors; however, adenosine A₁ and A_2A receptor (A₁R and A_2AR) mRNA expression is poorly understood in specific cell subtypes in the frontal cortical brain regions implicated in this disorder. In this study, we assayed A₁R and A_2AR mRNA expression via qPCR in enriched populations of pyramidal neurons, which were isolated from postmortem anterior cingulate cortex (ACC) tissue from schizophrenia (n = 20) and control (<

SUBMITTER: Sahay S 

PROVIDER: S-EPMC10778287 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature