The Role of TNF-α in Alzheimer's Disease: A Narrative Review.

ABSTRACT: This review analyzes the role of TNF-α and its increase in biological fluids in mild cognitive impairment, and Alzheimer's disease (AD). The potential inhibition of TNF-α with pharmacological strategies paves the way for preventing AD and improving cognitive function in people at risk for dementia. We conducted a narrative review to characterize the evidence in relation to the involvement of TNF-α in AD and its possible therapeutic inhibition. Several studies report that patients with RA and systemic inflammatory diseases treated with TNF-α blocking agents reduce the probability of emerging dementia compared with the general population. Animal model studies also showed interesting results and are discussed. An increasing amount of basic scientific data and clinical studies underscore the i

SUBMITTER: Plantone D 

PROVIDER: S-EPMC10778385 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature