Regulation of m⁶A Methylome in Cancer: Mechanisms, Implications, and Therapeutic Strategies.

ABSTRACT: Reversible N⁶-adenosine methylation of mRNA, referred to as m⁶A modification, has emerged as an important regulator of post-transcriptional RNA processing. Numerous studies have highlighted its crucial role in the pathogenesis of diverse diseases, particularly cancer. Post-translational modifications of m⁶A-related proteins play a fundamental role in regulating the m⁶A methylome, thereby influencing the fate of m⁶A-methylated RNA. A comprehensive understanding of the mechanisms that regulate m⁶A-related proteins and the factors contributing to the specificity of m⁶A deposition has the potential to unveil novel therapeutic strategies for cancer treatment. This review provides an in-depth overview of our curr

SUBMITTER: Bhattarai PY 

PROVIDER: S-EPMC10778393 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature