Extracellular Vesicles: Novel Potential Therapeutic Agents in Inflammatory Bowel Diseases.

ABSTRACT: Patients affected by inflammatory bowel diseases (IBD) can nowadays benefit from a growing number of pharmacological options. However, in moderate-to-severe cases, the therapeutic response is still far from optimal, and treatment changes and optimizations are often required. Thus, researchers in this field are strongly engaged in studies aiming to identify new potential therapeutic targets. Extracellular vesicles (EVs) are tiny subcellular bodies with a phospholipid bilayer envelope containing bioactive molecules, which are released from different cells and are involved in intercellular communication. Recent pre-clinical data show their emerging role in the pathogenesis and treatment of IBD. In our review, we summarize current evidence about the function of EVs as active therapeutic agents

SUBMITTER: Mignini I 

PROVIDER: S-EPMC10778449 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature