NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy.

ABSTRACT:

Background

Chronic kidney disease often leads to kidney dysfunction due to renal fibrosis, regardless of the initial cause of kidney damage. Macrophages are crucial players in the progression of renal fibrosis as they stimulate inflammation, activate fibroblasts, and contribute to extracellular matrix deposition, influenced by their metabolic state. Nucleotide-binding domain and LRR-containing protein X (NLRX1) is an innate immune receptor independent of inflammasomes and is found in mitochondria, and it plays a role in immune responses and cell metabolism. The specific impact of NLRX1 on macrophages and its involvement in renal fibrosis is not fully understood.

Methods

To explore the specific role of NLRX1 in macrophages, bone-marrow-derived macrophages (BMDMs) extracted fr

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10778504 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature