Targeting the Ubiquitin-Proteasome System and Recent Advances in Cancer Therapy.

ABSTRACT: Ubiquitination is a reversible post-translational modification based on the chemical addition of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination can alter the molecular functions of tagged substrates with respect to protein turnover, biological activity, subcellular localization or protein-protein interaction. As a result, a wide variety of cellular processes are under ubiquitination-mediated control, contributing to the maintenance of cellular homeostasis. It follows that the dysregulation of ubiquitination reactions plays a relevant role in the pathogenic states of human diseases such as neurodegenerative diseases, immune-related pathologies and cancer. In recent decades, the enzymes of the ubiquitin-proteasome system (UPS), including E3 ubiqui

SUBMITTER: Spano D 

PROVIDER: S-EPMC10778545 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature