The Duality of Adiponectin: The Role of Sex in Atherosclerosis.

ABSTRACT: The hormone adiponectin has many beneficial effects in atherosclerosis, as gene deficiency in adiponectin or its receptor has shown detrimental effects on plaque burden in mice. Our objective was to understand the potential roles adiponectin deficiency has on aortic plaque content, inflammation, and markers of cardiovascular disease according to sex and age. To study the influence of adiponectin status on sex and atherosclerosis, we used young male and female adipoq^-/-apoe^-/-, adipoq^+/-apoe^-/-, and apoe^-/- mice, which were given a high-fat diet (HFD). Even a 50% reduction in the expression of adiponectin led to a plaque reduction in males and an increase in females compared with apoe

SUBMITTER: Cullen AE 

PROVIDER: S-EPMC10778560 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature