Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks.

ABSTRACT: Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD) that poses a severe burden on the patients and caregivers, yet relatively little is known about its pathobiology. Cognitive deficits are evident throughout the course of PD, with around 25% of subtle cognitive decline and mild CI (MCI) at the time of diagnosis and up to 83% of patients developing dementia after 20 years. The heterogeneity of cognitive phenotypes suggests that a common neuropathological process, characterized by progressive degeneration of the dopaminergic striatonigral system and of many other neuronal systems, results not only in structural deficits but also extensive changes of functional neuronal network activities and neurotransmitter dysfunctions. Modern neuroimaging studies reve

SUBMITTER: Jellinger KA 

PROVIDER: S-EPMC10778722 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature