New Chalcone Derivatives Containing 2,4-Dichlorobenzenesulfonamide Moiety with Anticancer and Antioxidant Properties.

ABSTRACT: Chalcones and their derivatives, both natural and synthetic, exhibit diverse biological activities. In this study, we focused on designing and synthesizing (E)-2,4-dichloro-N-(4-cinnamoylphenyl)-5-methylbenzenesulfonamides 4-8 with the following two pharmacophore groups: 2,4-dichlorobenzenesulfonamide and chalcone. The obtained compounds displayed notable anticancer effects on various human cancer cells, such as cervical HeLa, acute promyelocytic leukemia HL-60, and gastric adenocarcinoma AGS, when assessed with the MTT test. The activity of all compounds against cancer cells was significant, and the obtained IC₅₀ values were in the range of 0.89-9.63 µg/mL. Among all the tested compounds, derivative 5 showed the highest activity on the AGS cel

SUBMITTER: Bulakowska A 

PROVIDER: S-EPMC10778824 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature