Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair.

ABSTRACT: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor activated canonically by numerous cytokines and other factors, with significant roles in immunity, immune diseases, and cancer. It has also been implicated in several human skeletal disorders, with loss-of-function (LOF) mutations associated with aberrant skeletal development. To gain further insights, two zebrafish STAT3 lines were investigated: a complete LOF knockout (KO) mutant and a partial LOF mutant with the transactivation domain truncated (ΔTAD). Consistent with other studies, the KO mutants were smaller, with reduced length in early embryos exacerbated by a decreased growth rate from 5 days postfertilization (dpf). They displayed skeletal deformities that approached 80% incidence by 30 dpf, with

SUBMITTER: Sobah ML 

PROVIDER: S-EPMC10778865 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature