Traces of Canine Inflammatory Bowel Disease Reflected by Intestinal Organoids.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic inflammatory condition that affects humans and several domestic animal species, including cats and dogs. In this study, we have analyzed duodenal organoids derived from canine IBD patients using quantitative proteomics. Our objective was to investigate whether these organoids show phenotypic traits of the disease compared with control organoids obtained from healthy donors. To this aim, IBD and control organoids were subjected to quantitative proteomics analysis via liquid chromatography-mass spectrometry. The obtained data revealed notable differences between the two groups. The IBD organoids exhibited several alterations at the levels of multiple proteins that are consistent with some known IBD alterations. The observed phenotype in the IBD o

SUBMITTER: Pratscher B 

PROVIDER: S-EPMC10778911 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature