Chitosan-Based Dressing as a Sustained Delivery System for Bioactive Cytokines.

ABSTRACT: Wounds represent a common occurrence in human life. Consequently, scientific investigations are underway to advance wound healing methodologies, with a notable focus on dressings imbued with biologically active compounds capable of orchestrating the wound microenvironment through meticulously regulated release mechanisms. Among these bioactive agents are cytokines, which, when administered to the wound milieu without appropriate protection, undergo rapid loss of their functional attributes. Within the context of this research, we present a method for fabricating dressings enriched with G-CSF (granulocyte colony-stimulating factor) or GM-CSF (granulocyte-macrophage colony-stimulating factor), showcasing both biological activity and protracted release dynamics. Based on Ligasano, a commercia

SUBMITTER: Lewicki S 

PROVIDER: S-EPMC10778940 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature