In Vivo and In Silico Studies of the Hepatoprotective Activity of Tert-Butylhydroquinone.

ABSTRACT: Tert-butylhydroquinone (TBHQ) is a synthetic food antioxidant with biological activities, but little is known about its pharmacological benefits in liver disease. Therefore, this work aimed to evaluate TBHQ during acute liver damage induced by CCl₄ (24 h) or BDL (48 h) in Wistar rats. It was found that pretreatment with TBHQ prevents 50% of mortality induced by a lethal dose of CCl₄ (4 g/kg, i.p.), and 80% of BDL+TBHQ rats survived, while only 50% of the BDL group survived. Serum markers of liver damage and macroscopic and microscopic (H&E staining) observations suggest that TBHQ protects from both hepatocellular necrosis caused by the sublethal dose of CCl₄ (1.6 g/kg, i.p.), as well as necrosis/ductal proliferation caused by BDL. Additionally, onlin

SUBMITTER: Aldaba-Muruato LR 

PROVIDER: S-EPMC10779046 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature