Toxicity of Metal Oxide Nanoparticles: Looking through the Lens of Toxicogenomics.

ABSTRACT: The impact of solubility on the toxicity of metal oxide nanoparticles (MONPs) requires further exploration to ascertain the impact of the dissolved and particulate species on response. In this study, FE1 mouse lung epithelial cells were exposed for 2-48 h to 4 MONPs of varying solubility: zinc oxide, nickel oxide, aluminum oxide, and titanium dioxide, in addition to microparticle analogues and metal chloride equivalents. Previously published data from FE1 cells exposed for 2-48 h to copper oxide and copper chloride were examined in the context of exposures in the present study. Viability was assessed using Trypan Blue staining and transcriptomic responses via microarray analysis. Results indicate material solubility is not the sole property governing MONP toxicity. Transcriptional signalin

SUBMITTER: Boyadzhiev A 

PROVIDER: S-EPMC10779048 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature