Ontology highlight
ABSTRACT:
SUBMITTER: Mircheva A
PROVIDER: S-EPMC10779140 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Mircheva Anastasiya A Vangrieken Philippe P Al-Nasiry Salwan S van Schooten Frederik-Jan FJ Godschalk Roger W L RWL Langie Sabine A S SAS
International journal of molecular sciences 20231222 1
The comet assay-based in vitro DNA repair assay has become a common tool for quantifying base excision repair (BER) activity in human lymphocytes or cultured cells. Here, we optimized the protocol for studying BER in human placental tissue because the placenta is a non-invasive tissue for biomonitoring of early-life exposures, and it can be used to investigate molecular mechanisms associated with prenatal disorders. The optimal protein concentration of placental protein extracts for optimal dama ...[more]