Effect of THz Waves of Different Orientations on K⁺ Permeation Efficiency in the KcsA Channel.

ABSTRACT: Potassium (K) channels show the highest variability and most frequent alterations in expression in many tumor types, and modulation of K⁺ channels may represent a new window for cancer therapy. In previous work, we found that a terahertz (THz) field incident along the z-axis with a frequency of 51.87 THz increased the ion flux through K⁺ channels. In practice, it is difficult to ensure that the incident electromagnetic (EM) wave is strictly parallel to the direction of channel ion flow. In this paper, we found by changing the direction of the applied electric field that the EM wave of a specific frequency has the largest ion flux when the incident direction is along the ion flow, and the smallest ion flux when the incident direction is perpendicular to the ion

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10779155 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature