Identification of Muscle Strength-Related Gut Microbes through Human Fecal Microbiome Transplantation.

ABSTRACT: The gut microbiome is well known for its influence on human physiology and aging. Therefore, we speculate that the gut microbiome may affect muscle strength in the same way as the host's own genes. To demonstrate candidates for gut microbes affecting muscle strength, we remodeled the original gut microbiome of mice into human intestinal microbiome through fecal microbiome transplantation (FMT), using human feces and compared the changes in muscle strength in the same mice before and three months after FMT. After comparing before and after FMT, the mice were divided into three groups based on the observed changes in muscle strength: positive, none, and negative changes in muscle strength. As a result of analyzing the α-diversity, β-diversity, and co-occurrence network of the intestinal micr

SUBMITTER: Ahn JS 

PROVIDER: S-EPMC10779158 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature