Identification of 2,4-Di-tert-butylphenol as a Novel Agonist for Insect Odorant Receptors.

ABSTRACT: Odorant molecules interact with odorant receptors (ORs) lining the pores on the surface of the sensilla on an insect's antennae and maxillary palps. This interaction triggers an electrical signal that is transmitted to the insect's nervous system, thereby influencing its behavior. Orco, an OR coreceptor, is crucial for olfactory transduction, as it possesses a conserved sequence across the insect lineage. In this study, we focused on 2,4-di-tert-butylphenol (DTBP), a single substance present in acetic acid bacteria culture media. We applied DTBP to oocytes expressing various Drosophila melanogaster odor receptors and performed electrophysiology experiments. After confirming the activation of DTBP on the receptor, the binding site was confirmed through point mutations. Our fin

SUBMITTER: Lee S 

PROVIDER: S-EPMC10779170 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature