Identification of MicroRNAs Associated with Histological Grade in Early-Stage Invasive Breast Cancer.

ABSTRACT: This study aimed to identify microRNAs associated with histological grade using comprehensive microRNA analysis data obtained by next-generation sequencing from early-stage invasive breast cancer. RNA-seq data from normal breast and breast cancer samples were compared to identify candidate microRNAs with differential expression using bioinformatics. A total of 108 microRNAs were significantly differentially expressed in normal breast and breast cancer tissues. Using clinicopathological information and microRNA sequencing data of 430 patients with breast cancer from The Cancer Genome Atlas (TCGA), the differences in candidate microRNAs between low- and high-grade tumors were identified. Comparing the expression of the 108 microRNAs between low- and high-grade cases, 25 and 18 microRNAs were

SUBMITTER: Kurozumi S 

PROVIDER: S-EPMC10779190 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature